Examples of drugs associated with CNS depression include pregabalin. Major Concomitant use of opioid agonists with suvorexant may cause respiratory depression, hypotension, profound sedation, and death. Prior to concurrent use of methadone in patients taking a CNS depressant, assess the level of tolerance to CNS depression that has developed, the duration of use, and the patient’s overall response to treatment. Methadone should be used with caution and in reduced dosages if used concurrently with a CNS depressant; also consider a using a lower dose of the CNS depressant. Constipation, GI disease, GI obstruction, ileus, inflammatory bowel disease, ulcerative colitis. Moderate Use caution when administering ivacaftor and alfentanil concurrently. Morphine and related opiates can produce spasm of the sphincter of Oddi.

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A size 3 in women or a size 4 in men cLMA was inserted 90 s after the injection of the first drug.

We’ll send you a link to reset your password. Major Concomitant use of opioid agonists with suvorexant may cause respiratory depression, hypotension, profound sedation, and death.

Practical aspects of alfentanil infusion.

Although opiate agonists are contraindicated for use in patients with diarrhea secondary to poisoning or infectious diarrhea, antimotility agents have been used successfully in these patients. The terminal half-life is 90— minutes.

If suvorexant is prescribed in a patient taking an opioid agonist, use a lower initial dose of suvorexant and titrate to clinical response. The sedative effect may be additive to other drugs with sedative actions, such as the opiate agonists. During cardiopulmonary bypass procedures, the volume of distribution, elimination half-life, and free fraction of alfentanil increase by a factor of 2—4.


Alfentanil has been reported to cross the placenta; however, no well-controlled studies in pregnant women have been performed.

Scottish Palliative Care Guidelines – Alfentanil

Monitor patients for adverse effects of alfentanil, such as hypotension, nausea, itching, and respiratory depression. A new password is required for A nesthesiology. Miosis is produced by an excitatory action on the autonomic segment of the nucleus of the oculomotor nerve. Opioids inhibit the secretion of adrenocorticotropic hormone ACTHcortisol, and luteinizing hormone LH ; however, the thyroid stimulating hormone may syrimge either stimulated or inhibited by opioids.

Required infusion rates are variable and should be titrated to the desired clinical dosd. Coadministration of opioid agonists with prasugrel delays and reduces the absorption of prasugrel’s active metabolite due to slowed gastric emptying. If lorlatinib is discontinued, consider alfentaanil the alfentanil dosage and monitor for evidence of respiratory depression. Alfentanil distribution half-lives are 1 and 14 minutes, and the terminal half-life is 90— minutes.

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The laryngeal mask airway: Unopened solutions should be discarded if a precipitate is present that does not disappear with shaking. Monitor patients for sedation and respiratory depression.

Muscle rigidity of alfentanl chest and abdominal muscles is often seen with opiate agonist anesthesia. Moderate Concomitant use of alfentanil with other CNS depressants, such as mirtazapine, can potentiate the effects of alfentanil on respiration, alertness, and blood pressure.

Caution and close monitoring are advised if these drugs are used together. Ensure proper placement of the needle when filling the reservoir to avoid accidental overdose.

Methyldopa can potentiate the effects of CNS depressants, such as opiate agonists, when administered concomitantly. Moderate Concomitant use of alfentanil with other CNS depressants, including tricyclic antidepressants TCAscan potentiate alfentanil-induced CNS and cardiovascular effects hypotension, changes in heart rate and the duration of these effects.


Moderate The concurrent use of trimethobenzamide with other medications that cause CNS depression, like opiate agonists, may potentiate the effects of either trimethobenzamide or the opiate agonist. Relation between fentanyl dose and predicted EC50 of propofol for laryngeal mask insertion.

Practical aspects of alfentanil infusion.

Major Concomitant use of opiate agonists with skeletal alfentanip relaxants may cause respiratory depression, hypotension, profound sedation, and death. Moderate Consider an increased dose of alfentanil and monitor for evidence of opioid withdrawal if coadministration with lorlatinib is necessary. Withdraw dose from the ampule through a 5-micrometer or smaller pore diameter microfilter doae avoid contamination with glass or other particles.

Moderate Ziprasidone has the potential to impair cognitive and motor skills. It undergoes liver biotransformation via cytochrome P isoenzyme 3A4. If duvelisib is discontinued, alfentanil plasma concentrations will decrease resulting in reduced efficacy of the opioid and potential withdrawal syndrome in aofentanil patient who has developed physical dependence to alfentanil.

Bismuth Subsalicylate; Metronidazole; Tetracycline: Only the optimum score ED 95 of Major The concomitant use of dabrafenib and alfentanil may lead to decreased alfentanil concentrations and loss of efficacy.